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KMID : 0364219920350020144
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Korean Journal of Zoology
1992 Volume.35 No. 2 p.144 ~ p.148
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Changes in the Level of Transferrin Receptor during the Differentiation of Chick Brain Neuroblasts
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Lee Chang-Ho
Jeon Young-Ju
Namkoong Yong
Park Young-Chul
Chung Chin-Ha
Ha Doo-Bong
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Abstract
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Insulin and transfenin (Tf) were found to be essential for suwival and differentiation of brain neuroblasts obtained from chick embryo. This requirement, however, is Changed from insulin to Tf upon neuronal development of the embryo, and this phenomenon is due to the changes in the levels of corresponding receptors. Using cultured neuroblasts, the level of Tf receptor is also found to increase Lvhile that of insulin receptor falls dramatically during the course of the cell differentiation. These results suggest that the development-specific changes in the levels of insulin and Tf receptors in embryo can be reproduced in the culture system during the differentiation period. Because the culture system used was a defined medium and contained no other macromolecules than insulin and Tf, it appears possible that insulin and Tf may act as signalling molecules in the control of neuronal development.
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KEYWORD
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Transferrin, Insulin, Neuroblast, differentiation
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